Publications

2016
Title Effects of BMS-986094, a Guanosine Nucleotide Analogue, on Mitochondrial DNA Synthesis and Function.
Authors Baumgart BR, Wang F, Kwagh J, Storck C, Euler C, Fuller M, Simic D, Sharma S, Arnold JJ, Cameron CE, Van Vleet TR, Flint O, Bunch RT, Davies MH, Graziano MJ, Sanderson TP.
Journal Toxicol Sci. 2016 Jul 27. pii: kfw135. [Epub ahead of print]
Title Biochemical and genetic analysis of the role of the viral polymerase in enterovirus recombination.
Authors Woodman A, Arnold JJ, Cameron CE, Evans DJ.
Journal Nucleic Acids Res. 2016 Jun 17. pii: gkw567. [Epub ahead of print]
Title Acoustofluidic Transfer of Inflammatory Cells from Human Sputum Samples.
Authors Li S, Ren L, Huang PH, Yao X, Cuento RA, McCoy JP, Cameron CE, Levine SJ, Huang TJ.
Journal Anal Chem. 2016 Jun 7;88(11):5655-61. doi: 10.1021/acs.analchem.5b03383. Epub 2016 May 16.
Title Long-Range Communication between Different Functional Sites in the Picornaviral 3C Protein.
Authors Chan YM, Moustafa IM, Arnold JJ, Cameron CE, Boehr DD.
Journal Structure. 2016 Apr 5;24(4):509-17. doi: 10.1016/j.str.2016.02.019.
Title Conformational Ensemble of the Poliovirus 3CD Precursor Observed by MD Simulations and Confirmed by SAXS: A Strategy to Expand the Viral Proteome?
Authors Moustafa IM, Gohara DW, Uchida A, Yennawar N, Cameron CE.
Journal Viruses. 2015 Nov 23;7(11):5962-86. doi: 10.3390/v7112919.
Title Expression and Purification of Mitochondrial RNA Polymerase and Transcription Factor A from Drosophila melanogaster.
Authors Gajewski JP, Arnold JJ, Salminen TS, Kaguni LS, Cameron CE.
Journal Methods Mol Biol. 2016;1351:199-210. doi: 10.1007/978-1-4939-3040-1_15.
Title Nucleobase but not Sugar Fidelity is Maintained in the Sabin I RNA-Dependent RNA Polymerase.
Authors Liu X, Musser DM, Lee CA, Yang X, Arnold JJ, Cameron CE, Boehr DD.
Journal Viruses. 2015 Oct 26;7(10):5571-86. doi: 10.3390/v7102894.
Title Polymerase Mechanism-Based Method of Viral Attenuation.
Authors Lee CA, August A, Arnold JJ, Cameron CE.
Journal Methods Mol Biol. 2016;1349:83-104. doi: 10.1007/978-1-4939-3008-1_6.

2015
Title Sequence-Specific Fidelity Alterations Associated with West Nile Virus Attenuation in Mosquitoes.
Authors Van Slyke GA, Arnold JJ, Lugo AJ, Griesemer SB, Moustafa IM, Kramer LD, Cameron CE, Ciota AT.
Journal PLoS Pathog. 2015 Jun 26;11(6):e1005009. doi: 10.1371/journal.ppat.1005009. eCollection 2015 Jun.
Title 26 Sequence-specific DNA looping by mitochondrial transcription factor A (TFAM).
Authors Murugesapillai D, Lodeiro MF, James Maher L 3rd, Cameron CE, Williams MC.
Journal J Biomol Struct Dyn. 2015;33 Suppl 1:15-6. doi: 10.1080/07391102.2015.1032566. No abstract available.
Title Melting of Duplex DNA in the Absence of ATP by the NS3 Helicase Domain through Specific Interaction with a Single-Strand/Double-Strand Junction.
Authors Reynolds KA, Cameron CE, Raney KD.
Journal Biochemistry. 2015 Jul 14;54(27):4248-58. doi: 10.1021/acs.biochem.5b00214. Epub 2015 Jul 2.
Title Effect of Casting Material on the Cast Pressure After Sequential Cast Splitting.
Authors Roberts A, Shaw KA, Boomsma SE, Cameron CD.
Journal J Pediatr Orthop. 2015 Jun 17. [Epub ahead of print]
Title Structural models of mammalian mitochondrial transcription factor B2.
Authors Moustafa IM, Uchida A, Wang Y, Yennawar N, Cameron CE.
Journal Biochim Biophys Acta. 2015 Aug;1849(8):987-1002. doi: 10.1016/j.bbagrm.2015.05.010. Epub 2015 Jun 8.
Title The RNA template channel of the RNA-dependent RNA polymerase as a target for development of antiviral therapy of multiple genera within a virus family.
Authors van der Linden L, Vives-Adrián L, Selisko B, Ferrer-Orta C, Liu X, Lanke K, Ulferts R, De Palma AM, Tanchis F, Goris N, Lefebvre D, De Clercq K, Leyssen P, Lacroix C, Pürstinger G, Coutard B, Canard B, Boehr DD, Arnold JJ, Cameron CE, Verdaguer N, Neyts J, van Kuppeveld FJ.
Journal PLoS Pathog. 2015 Mar 23;11(3):e1004733. doi: 10.1371/journal.ppat.1004733. eCollection 2015 Mar.
2014
Title Structure-function analysis of vaccinia virus H7 protein reveals a novel phosphoinositide binding fold essential for poxvirus replication.
Authors Kolli S, Meng X, Wu X, Shengjuler D, Cameron CE, Xiang Y, Deng J.
Journal J Virol. 2015 Feb;89(4):2209-19. doi: 10.1128/JVI.03073-14. Epub 2014 Dec 3.
Title Electrochemically Created Highly Surface Roughened Ag Nanoplate Arrays for SERS Biosensing Applications.
Authors Yang S, Slotcavage D, Mai JD, Guo F, Li S, Zhao Y, Lei Y, Cameron CE, Huang TJ.
Journal J Mater Chem C Mater Opt Electron Devices. 2014 Oct 21;2(39):8350-8356.
Title Structural dynamics as a contributor to error-prone replication by an RNA-dependent RNA polymerase.
Authors Moustafa IM, Korboukh VK, Arnold JJ, Smidansky ED, Marcotte LL, Gohara DW, Yang X, Sánchez-Farrán MA, Filman D, Maranas JK, Boehr DD, Hogle JM, Colina CM, Cameron CE.
Journal J Biol Chem. 2014 Dec 26;289(52):36229-48. doi: 10.1074/jbc.M114.616193. Epub 2014 Nov 6.
Title Standing surface acoustic wave (SSAW)-based cell washing.
Authors Li S, Ding X, Mao Z, Chen Y, Nama N, Guo F, Li P, Wang L, Cameron CE, Huang TJ.
Journal Lab Chip. 2015 Jan 7;15(1):331-8. doi: 10.1039/c4lc00903g.
Title Kinetic analysis of human PrimPol DNA polymerase activity reveals a generally error-prone enzyme capable of accurately bypassing 7,8-dihydro-8-oxo-2′-deoxyguanosine.
Authors Zafar MK, Ketkar A, Lodeiro MF, Cameron CE, Eoff RL.
Journal Biochemistry. 2014 Oct 21;53(41):6584-94. doi: 10.1021/bi501024u. Epub 2014 Oct 10.
Title Standing surface acoustic wave based cell coculture.
Authors Li S, Guo F, Chen Y, Ding X, Li P, Wang L, Cameron CE, Huang TJ.
Journal Anal Chem. 2014 Oct 7;86(19):9853-9. doi: 10.1021/ac502453z. Epub 2014 Sep 18.
Title RNA virus population diversity, an optimum for maximal fitness and virulence.
Authors Korboukh VK, Lee CA, Acevedo A, Vignuzzi M, Xiao Y, Arnold JJ, Hemperly S, Graci JD, August A, Andino R, Cameron CE.
Journal J Biol Chem. 2014 Oct 24;289(43):29531-44. doi: 10.1074/jbc.M114.592303. Epub 2014 Sep 11.
Title Expanding the proteome of an RNA virus by phosphorylation of an intrinsically disordered viral protein.
Authors Cordek DG, Croom-Perez TJ, Hwang J, Hargittai MR, Subba-Reddy CV, Han Q, Lodeiro MF, Ning G, McCrory TS, Arnold JJ, Koc H, Lindenbach BD, Showalter SA, Cameron CE.
Journal J Biol Chem. 2014 Aug 29;289(35):24397-416. doi: 10.1074/jbc.M114.589911. Epub 2014 Jul 16.
Title Cytoplasmic viral RNA-dependent RNA polymerase disrupts the intracellular splicing machinery by entering the nucleus and interfering with Prp8.
Authors Liu YC, Kuo RL, Lin JY, Huang PN, Huang Y, Liu H, Arnold JJ, Chen SJ, Wang RY, Cameron CE, Shih SR.
Journal PLoS Pathog. 2014 Jun 26;10(6):e1004199. doi: 10.1371/journal.ppat.1004199. eCollection 2014 Jun.
Title Cystoviral polymerase complex protein P7 uses its acidic C-terminal tail to regulate the RNA-directed RNA polymerase P2.
Authors Alphonse S, Arnold JJ, Bhattacharya S, Wang H, Kloss B, Cameron CE, Ghose R.
Journal J Mol Biol. 2014 Jul 15;426(14):2580-93. doi: 10.1016/j.jmb.2014.04.028. Epub 2014 May 9.
Title Computational Analysis of Amiloride Analogue Inhibitors of Coxsackievirus B3 RNA Polymerase.
Authors Holien JK, Gazina EV, Elliott RW, Jarrott B, Cameron CE, Williams SJ, Parker MW, Petrou S.
Journal J Proteomics Bioinform. 2014;Suppl 9:004. Epub 2014 Aug 12.

2013
Title Vaccine-derived mutation in motif D of poliovirus RNA-dependent RNA polymerase lowers nucleotide incorporation fidelity.
Authors Liu X, Yang X, Lee CA, Moustafa IM, Smidansky ED, Lum D, Arnold JJ, Cameron CE, Boehr DD.
Journal J Biol Chem. 2013 Nov 8;288(45):32753-65. doi: 10.1074/jbc.M113.484428. Epub 2013 Sep 30.
Title Microfluidic opportunities in the field of nutrition.
Authors Li S, Kiehne J, Sinoway LI, Cameron CE, Huang TJ.
Journal Lab Chip. 2013 Oct 21;13(20):3993-4003. doi: 10.1039/c3lc90090h. Review.
Title Interferon and ribavirin combination treatment synergistically inhibit HCV internal ribosome entry site mediated translation at the level of polyribosome formation.
Authors Panigrahi R, Hazari S, Chandra S, Chandra PK, Datta S, Kurt R, Cameron CE, Huang Z, Zhang H, Garry RF, Balart LA, Dash S.
Journal PLoS One. 2013 Aug 23;8(8):e72791. doi: 10.1371/journal.pone.0072791. eCollection 2013.
Title An on-chip, multichannel droplet sorter using standing surface acoustic waves.
Authors Li S, Ding X, Guo F, Chen Y, Lapsley MI, Lin SC, Wang L, McCoy JP, Cameron CE, Huang TJ.
Journal Anal Chem. 2013 Jun 4;85(11):5468-74. doi: 10.1021/ac400548d. Epub 2013 May 23.
Title Native tertiary structure and nucleoside modifications suppress tRNA’s intrinsic ability to activate the innate immune sensor PKR.
Authors Nallagatla SR, Jones CN, Ghosh SK, Sharma SD, Cameron CE, Spremulli LL, Bevilacqua PC.
Journal PLoS One. 2013;8(3):e57905. doi: 10.1371/journal.pone.0057905. Epub 2013 Mar 4.

2012
Title Sensitivity of mitochondrial transcription and resistance of RNA polymerase II dependent nuclear transcription to antiviral ribonucleosides.
Authors Arnold JJ, Sharma SD, Feng JY, Ray AS, Smidansky ED, Kireeva ML, Cho A, Perry J, Vela JE, Park Y, Xu Y, Tian Y, Babusis D, Barauskus O, Peterson BR, Gnatt A, Kashlev M, Zhong W, Cameron CE.
Journal PLoS Pathog. 2012;8(11):e1003030. doi: 10.1371/journal.ppat.1003030. Epub 2012 Nov 15.
Title Exploring the dynamics of four RNA-dependent RNA polymerases by a coarse-grained model.
Authors Shen H, Moustafa IM, Cameron CE, Colina CM.
Journal J Phys Chem B. 2012 Dec 20;116(50):14515-24. doi: 10.1021/jp302709v. Epub 2012 Dec 7.
Title Binding by the hepatitis C virus NS3 helicase partially melts duplex DNA.
Authors Raney VM, Reynolds KA, Harrison MK, Harrison DK, Cameron CE, Raney KD.
Journal Biochemistry. 2012 Sep 25;51(38):7596-607. doi: 10.1021/bi300654v. Epub 2012 Sep 13.
Title A Polymerase mechanism-based strategy for viral attenuation and vaccine development.
Authors Weeks SA, Lee CA, Zhao Y, Smidansky ED, August A, Arnold JJ, Cameron CE.
Journal J Biol Chem. 2012 Sep 14;287(38):31618-22. doi: 10.1074/jbc.C112.401471. Epub 2012 Aug 1.
Title Mitochondrial gene expression.
Authors Cameron CE, Cline SD.
Journal Biochim Biophys Acta. 2012 Sep-Oct;1819(9-10):913. doi: 10.1016/j.bbagrm.2012.07.002. No abstract available.
Title Motif D of viral RNA-dependent RNA polymerases determines efficiency and fidelity of nucleotide addition.
Authors Yang X, Smidansky ED, Maksimchuk KR, Lum D, Welch JL, Arnold JJ, Cameron CE, Boehr DD.
Journal Structure. 2012 Sep 5;20(9):1519-27. doi: 10.1016/j.str.2012.06.012. Epub 2012 Jul 19.
Title Correlation between NS5A dimerization and hepatitis C virus replication.
Authors Lim PJ, Chatterji U, Cordek D, Sharma SD, Garcia-Rivera JA, Cameron CE, Lin K, Targett-Adams P, Gallay PA.
Journal J Biol Chem. 2012 Aug 31;287(36):30861-73. doi: 10.1074/jbc.M112.376822. Epub 2012 Jul 16.
Title Poliovirus infection transiently increases COPII vesicle budding.
Authors Trahey M, Oh HS, Cameron CE, Hay JC.
Journal J Virol. 2012 Sep;86(18):9675-82. doi: 10.1128/JVI.01159-12. Epub 2012 Jun 27.
Title Human mitochondrial RNA polymerase: structure-function, mechanism and inhibition.
Authors Arnold JJ, Smidansky ED, Moustafa IM, Cameron CE.
Journal Biochim Biophys Acta. 2012 Sep-Oct;1819(9-10):948-60. doi: 10.1016/j.bbagrm.2012.04.002. Epub 2012 Apr 19. Review.
Title Transcription from the second heavy-strand promoter of human mtDNA is repressed by transcription factor A in vitro.
Authors Lodeiro MF, Uchida A, Bestwick M, Moustafa IM, Arnold JJ, Shadel GS, Cameron CE.
Journal Proc Natl Acad Sci U S A. 2012 Apr 24;109(17):6513-8. doi: 10.1073/pnas.1118710109. Epub 2012 Apr 9.
Title The 3′ untranslated regions of influenza genomic sequences are 5’PPP-independent ligands for RIG-I.
Authors Davis WG, Bowzard JB, Sharma SD, Wiens ME, Ranjan P, Gangappa S, Stuchlik O, Pohl J, Donis RO, Katz JM, Cameron CE, Fujita T, Sambhara S.
Journal PLoS One. 2012;7(3):e32661. doi: 10.1371/journal.pone.0032661. Epub 2012 Mar 15.
Title Mutational robustness of an RNA virus influences sensitivity to lethal mutagenesis.
Authors Graci JD, Gnädig NF, Galarraga JE, Castro C, Vignuzzi M, Cameron CE.
Journal J Virol. 2012 Mar;86(5):2869-73. doi: 10.1128/JVI.05712-11. Epub 2011 Dec 21.

2011
Title Amiloride is a competitive inhibitor of coxsackievirus B3 RNA polymerase.
Authors Gazina EV, Smidansky ED, Holien JK, Harrison DN, Cromer BA, Arnold JJ, Parker MW, Cameron CE, Petrou S.
Journal J Virol. 2011 Oct;85(19):10364-74. doi: 10.1128/JVI.05022-11. Epub 2011 Jul 27.
Title Intermolecular interactions within the abundant DEAD-box protein Dhh1 regulate its activity in vivo.
Authors Dutta A, Zheng S, Jain D, Cameron CE, Reese JC.
Journal J Biol Chem. 2011 Aug 5;286(31):27454-70. doi: 10.1074/jbc.M111.220251. Epub 2011 Jun 3.
Title Molecular dynamics simulations of viral RNA polymerases link conserved and correlated motions of functional elements to fidelity.
Authors Moustafa IM, Shen H, Morton B, Colina CM, Cameron CE.
Journal J Mol Biol. 2011 Jul 1;410(1):159-81. doi: 10.1016/j.jmb.2011.04.078. Epub 2011 May 7.
Title Human mitochondrial RNA polymerase: evaluation of the single-nucleotide-addition cycle on synthetic RNA/DNA scaffolds.
Authors Smidansky ED, Arnold JJ, Reynolds SL, Cameron CE.
Journal Biochemistry. 2011 Jun 7;50(22):5016-32. doi: 10.1021/bi200350d. Epub 2011 May 12. Erratum in: Biochemistry. 2011 Jul 5;50(26):5969.

2010
Title Synthesis of a 6-methyl-7-deaza analogue of adenosine that potently inhibits replication of polio and dengue viruses.
Authors Wu R, Smidansky ED, Oh HS, Takhampunya R, Padmanabhan R, Cameron CE, Peterson BR.
Journal J Med Chem. 2010 Nov 25;53(22):7958-66. doi: 10.1021/jm100593s. Epub 2010 Oct 22.
Title Hepatitis C virus nonstructural protein 5A: biochemical characterization of a novel structural class of RNA-binding proteins.
Authors Hwang J, Huang L, Cordek DG, Vaughan R, Reynolds SL, Kihara G, Raney KD, Kao CC, Cameron CE.
Journal J Virol. 2010 Dec;84(24):12480-91. doi: 10.1128/JVI.01319-10. Epub 2010 Oct 6.
Title Arrest of human mitochondrial RNA polymerase transcription by the biological aldehyde adduct of DNA, M1dG.
Authors Cline SD, Lodeiro MF, Marnett LJ, Cameron CE, Arnold JJ.
Journal Nucleic Acids Res. 2010 Nov;38(21):7546-57. doi: 10.1093/nar/gkq656. Epub 2010 Jul 29.
Title Core human mitochondrial transcription apparatus is a regulated two-component system in vitro.
Authors Shutt TE, Lodeiro MF, Cotney J, Cameron CE, Shadel GS.
Journal Proc Natl Acad Sci U S A. 2010 Jul 6;107(27):12133-8. doi: 10.1073/pnas.0910581107. Epub 2010 Jun 18.
Title Expanding knowledge of P3 proteins in the poliovirus lifecycle.
Authors Cameron CE, Oh HS, Moustafa IM.
Journal Future Microbiol. 2010 Jun;5(6):867-81. doi: 10.2217/fmb.10.40. Review.
Title Viral reorganization of the secretory pathway generates distinct organelles for RNA replication.
Authors Hsu NY, Ilnytska O, Belov G, Santiana M, Chen YH, Takvorian PM, Pau C, van der Schaar H, Kaushik-Basu N, Balla T, Cameron CE, Ehrenfeld E, van Kuppeveld FJ, Altan-Bonnet N.
Journal Cell. 2010 May 28;141(5):799-811. doi: 10.1016/j.cell.2010.03.050.
Title Hepatitis C virus non-structural protein 3 (HCV NS3): a multifunctional antiviral target.
Authors Raney KD, Sharma SD, Moustafa IM, Cameron CE.
Journal J Biol Chem. 2010 Jul 23;285(30):22725-31. doi: 10.1074/jbc.R110.125294. Epub 2010 May 10. Review.
Title HCV resistance to cyclosporin A does not correlate with a resistance of the NS5A-cyclophilin A interaction to cyclophilin inhibitors.
Authors Chatterji U, Lim P, Bobardt MD, Wieland S, Cordek DG, Vuagniaux G, Chisari F, Cameron CE, Targett-Adams P, Parkinson T, Gallay PA.
Journal J Hepatol. 2010 Jul;53(1):50-6. doi: 10.1016/j.jhep.2010.01.041. Epub 2010 Apr 3.
Title Regulation of PKR by HCV IRES RNA: importance of domain II and NS5A.
Authors Toroney R, Nallagatla SR, Boyer JA, Cameron CE, Bevilacqua PC.
Journal J Mol Biol. 2010 Jul 16;400(3):393-412. doi: 10.1016/j.jmb.2010.04.059. Epub 2010 May 4.
Title Identification of multiple rate-limiting steps during the human mitochondrial transcription cycle in vitro.
Authors Lodeiro MF, Uchida AU, Arnold JJ, Reynolds SL, Moustafa IM, Cameron CE.
Journal J Biol Chem. 2010 May 21;285(21):16387-402. doi: 10.1074/jbc.M109.092676. Epub 2010 Mar 29.
Title Investigation of translocation, DNA unwinding, and protein displacement by NS3h, the helicase domain from the hepatitis C virus helicase.
Authors Matlock DL, Yeruva L, Byrd AK, Mackintosh SG, Langston C, Brown C, Cameron CE, Fischer CJ, Raney KD.
Journal Biochemistry. 2010 Mar 16;49(10):2097-109. doi: 10.1021/bi901977k.
Title Phosphate release contributes to the rate-limiting step for unwinding by an RNA helicase.
Authors Wang Q, Arnold JJ, Uchida A, Raney KD, Cameron CE.
Journal Nucleic Acids Res. 2010 Mar;38(4):1312-24. doi: 10.1093/nar/gkp1118. Epub 2009 Dec 6.
Title Dynamics: the missing link between structure and function of the viral RNA-dependent RNA polymerase?
Authors Cameron CE, Moustafa IM, Arnold JJ.
Journal Curr Opin Struct Biol. 2009 Dec;19(6):768-74. doi: 10.1016/j.sbi.2009.10.012. Epub 2009 Nov 10. Review.
Title The RNA polymerase activity of SARS-coronavirus nsp12 is primer dependent.
Authors te Velthuis AJ, Arnold JJ, Cameron CE, van den Worm SH, Snijder EJ.
Journal Nucleic Acids Res. 2010 Jan;38(1):203-14. doi: 10.1093/nar/gkp904. Epub 2009 Oct 29. Erratum in: Nucleic Acids Res. 2011 Nov;39(21):9458.

2009
Title Therapeutically targeting RNA viruses via lethal mutagenesis.
Authors Graci JD, Cameron CE.
Journal Future Virol. 2008 Nov;3(6):553-566.
Title Insight into poliovirus genome replication and encapsidation obtained from studies of 3B-3C cleavage site mutants.
Authors Oh HS, Pathak HB, Goodfellow IG, Arnold JJ, Cameron CE.
Journal J Virol. 2009 Sep;83(18):9370-87. doi: 10.1128/JVI.02076-08. Epub 2009 Jul 8.
Title Nucleic acid polymerases use a general acid for nucleotidyl transfer.
Authors Castro C, Smidansky ED, Arnold JJ, Maksimchuk KR, Moustafa I, Uchida A, Götte M, Konigsberg W, Cameron CE.
Journal Nat Struct Mol Biol. 2009 Feb;16(2):212-8. doi: 10.1038/nsmb.1540. Epub 2009 Jan 18.
Title NS3 helicase from the hepatitis C virus can function as a monomer or oligomer depending on enzyme and substrate concentrations.
Authors Jennings TA, Mackintosh SG, Harrison MK, Sikora D, Sikora B, Dave B, Tackett AJ, Cameron CE, Raney KD.
Journal J Biol Chem. 2009 Feb 20;284(8):4806-14. doi: 10.1074/jbc.M805540200. Epub 2008 Dec 16.

2008
Title Determinants of RNA-dependent RNA polymerase (in)fidelity revealed by kinetic analysis of the polymerase encoded by a foot-and-mouth disease virus mutant with reduced sensitivity to ribavirin.
Authors Arias A, Arnold JJ, Sierra M, Smidansky ED, Domingo E, Cameron CE.
Journal J Virol. 2008 Dec;82(24):12346-55. doi: 10.1128/JVI.01297-08. Epub 2008 Oct 1.
Title Picornavirus genome replication: roles of precursor proteins and rate-limiting steps in oriI-dependent VPg uridylylation.
Authors Pathak HB, Oh HS, Goodfellow IG, Arnold JJ, Cameron CE.
Journal J Biol Chem. 2008 Nov 7;283(45):30677-88. doi: 10.1074/jbc.M806101200. Epub 2008 Sep 8.
Title One-pot synthesis of nucleoside 5′-triphosphates from nucleoside 5′-H-phosphonates.
Authors Sun Q, Edathil JP, Wu R, Smidansky ED, Cameron CE, Peterson BR.
Journal Org Lett. 2008 May 1;10(9):1703-6. doi: 10.1021/ol8003029. Epub 2008 Apr 8.
Title Hepatitis C virus NS3 helicase forms oligomeric structures that exhibit optimal DNA unwinding activity in vitro.
Authors Sikora B, Chen Y, Lichti CF, Harrison MK, Jennings TA, Tang Y, Tackett AJ, Jordan JB, Sakon J, Cameron CE, Raney KD.
Journal J Biol Chem. 2008 Apr 25;283(17):11516-25. doi: 10.1074/jbc.M708125200. Epub 2008 Feb 18.
Title Structure-function relationships among RNA-dependent RNA polymerases.
Authors Ng KK, Arnold JJ, Cameron CE.
Journal Curr Top Microbiol Immunol. 2008;320:137-56. Review.
Title Lethal mutagenesis of picornaviruses with N-6-modified purine nucleoside analogues.
Authors Graci JD, Too K, Smidansky ED, Edathil JP, Barr EW, Harki DA, Galarraga JE, Bollinger JM Jr, Peterson BR, Loakes D, Brown DM, Cameron CE.
Journal Antimicrob Agents Chemother. 2008 Mar;52(3):971-9. doi: 10.1128/AAC.01056-07. Epub 2008 Jan 7.
Title RNA unwinding activity of the hepatitis C virus NS3 helicase is modulated by the NS5B polymerase.
Authors Jennings TA, Chen Y, Sikora D, Harrison MK, Sikora B, Huang L, Jankowsky E, Fairman ME, Cameron CE, Raney KD.
Journal Biochemistry. 2008 Jan 29;47(4):1126-35. doi: 10.1021/bi701048a. Epub 2008 Jan 8.
Title Effects of introduction of hydrophobic group on ribavirin base on mutation induction and anti-RNA viral activity.
Authors Moriyama K, Suzuki T, Negishi K, Graci JD, Thompson CN, Cameron CE, Watanabe M.
Journal J Med Chem. 2008 Jan 10;51(1):159-66. Epub 2007 Dec 8.
Title 5′-triphosphate-dependent activation of PKR by RNAs with short stem-loops.
Authors Nallagatla SR, Hwang J, Toroney R, Zheng X, Cameron CE, Bevilacqua PC.
Journal Science. 2007 Nov 30;318(5855):1455-8.
Title Picornavirus genome replication. Identification of the surface of the poliovirus (PV) 3C dimer that interacts with PV 3Dpol during VPg uridylylation and construction of a structural model for the PV 3C2-3Dpol complex.
Authors Shen M, Reitman ZJ, Zhao Y, Moustafa I, Wang Q, Arnold JJ, Pathak HB, Cameron CE.
Journal J Biol Chem. 2008 Jan 11;283(2):875-88. Epub 2007 Nov 9.

2007
Title Human rhinovirus type 14 gain-of-function mutants for oriI utilization define residues of 3C(D) and 3Dpol that contribute to assembly and stability of the picornavirus VPg uridylylation complex.
Authors Shen M, Wang Q, Yang Y, Pathak HB, Arnold JJ, Castro C, Lemon SM, Cameron CE.
Journal J Virol. 2007 Nov;81(22):12485-95. Epub 2007 Sep 12.
Title Lethal mutagenesis of poliovirus mediated by a mutagenic pyrimidine analogue.
Authors Graci JD, Harki DA, Korneeva VS, Edathil JP, Too K, Franco D, Smidansky ED, Paul AV, Peterson BR, Brown DM, Loakes D, Cameron CE.
Journal J Virol. 2007 Oct;81(20):11256-66. Epub 2007 Aug 8.
Title Synthesis of a universal 5-nitroindole ribonucleotide and incorporation into RNA by a viral RNA-dependent RNA polymerase.
Authors Harki DA, Graci JD, Edathil JP, Castro C, Cameron CE, Peterson BR.
Journal Chembiochem. 2007 Aug 13;8(12):1359-62. No abstract available.
Title Structure-function relationships of the viral RNA-dependent RNA polymerase: fidelity, replication speed, and initiation mechanism determined by a residue in the ribose-binding pocket.
Authors Korneeva VS, Cameron CE.
Journal J Biol Chem. 2007 Jun 1;282(22):16135-45. Epub 2007 Mar 29.
Title Picornavirus genome replication: assembly and organization of the VPg uridylylation ribonucleoprotein (initiation) complex.
Authors Pathak HB, Arnold JJ, Wiegand PN, Hargittai MR, Cameron CE.
Journal J Biol Chem. 2007 Jun 1;282(22):16202-13. Epub 2007 Mar 27.
Title Two proton transfers in the transition state for nucleotidyl transfer catalyzed by RNA- and DNA-dependent RNA and DNA polymerases.
Authors Castro C, Smidansky E, Maksimchuk KR, Arnold JJ, Korneeva VS, Götte M, Konigsberg W, Cameron CE.
Journal Proc Natl Acad Sci U S A. 2007 Mar 13;104(11):4267-72. Epub 2007 Mar 5.
Title Crystal structure of poliovirus 3CD protein: virally encoded protease and precursor to the RNA-dependent RNA polymerase.
Authors Marcotte LL, Wass AB, Gohara DW, Pathak HB, Arnold JJ, Filman DJ, Cameron CE, Hogle JM.
Journal J Virol. 2007 Apr;81(7):3583-96. Epub 2007 Jan 24.

2006
Title Synthesis and antiviral activity of 5-substituted cytidine analogues: identification of a potent inhibitor of viral RNA-dependent RNA polymerases.
Authors Harki DA, Graci JD, Galarraga JE, Chain WJ, Cameron CE, Peterson BR.
Journal J Med Chem. 2006 Oct 19;49(21):6166-9.
Title Control of template positioning during de novo initiation of RNA synthesis by the bovine viral diarrhea virus NS5B polymerase.
Authors D’Abramo CM, Deval J, Cameron CE, Cellai L, Götte M.
Journal J Biol Chem. 2006 Aug 25;281(34):24991-8. Epub 2006 Jun 29.
Title Inhibition of dengue virus replication by mycophenolic acid and ribavirin.
Authors Takhampunya R, Ubol S, Houng HS, Cameron CE, Padmanabhan R.
Journal J Gen Virol. 2006 Jul;87(Pt 7):1947-52.
Title Molecular and biological characterization of deformed wing virus of honeybees (Apis mellifera L.).
Authors Lanzi G, de Miranda JR, Boniotti MB, Cameron CE, Lavazza A, Capucci L, Camazine SM, Rossi C.
Journal J Virol. 2006 May;80(10):4998-5009.
Title Protocol for siRNA-Primed RNA Synthesis.
Authors Huang L, Gledhill J, Cameron CE.
Journal CSH Protoc. 2006 Jun 1;2006(1). pii: pdb.prot4326. doi: 10.1101/pdb.prot4326. No abstract available.
Title Preparation of siRNAs from Drosophila Embryo Extracts.
Authors Huang L, Gledhill J, Cameron CE.
Journal CSH Protoc. 2006 Jun 1;2006(1). pii: pdb.prot4325. doi: 10.1101/pdb.prot4325. No abstract available.
Title Preparation and Fractionation of Drosophila Embryo Extracts for the In Vitro Characterization of RNAi.
Authors Huang L, Gledhill J, Cameron CE.
Journal CSH Protoc. 2006 Jun 1;2006(1). pii: pdb.prot4324. doi: 10.1101/pdb.prot4324. No abstract available.
Title Assay for Primed RNA-Dependent RNA Polymerase Transcription.
Authors Huang L, Gledhill J, Cameron CE.
Journal CSH Protoc. 2006 Jun 1;2006(1). pii: pdb.prot4323. doi: 10.1101/pdb.prot4323. No abstract available.
Title An Assay for RNA-Dependent RNA Polymerase Activity.
Authors Huang L, Gledhill J, Cameron CE.
Journal CSH Protoc. 2006 Jun 1;2006(1). pii: pdb.prot4322. doi: 10.1101/pdb.prot4322. No abstract available.
Title Structural and functional characterization of the coxsackievirus B3 CRE(2C): role of CRE(2C) in negative- and positive-strand RNA synthesis.
Authors van Ooij MJ, Vogt DA, Paul A, Castro C, Kuijpers J, van Kuppeveld FJ, Cameron CE, Wimmer E, Andino R, Melchers WJ.
Journal J Gen Virol. 2006 Jan;87(Pt 1):103-13.
Title Small ubiquitin-like modifying protein isopeptidase assay based on poliovirus RNA polymerase activity.
Authors Arnold JJ, Bernal A, Uche U, Sterner DE, Butt TR, Cameron CE, Mattern MR.
Journal Anal Biochem. 2006 Mar 15;350(2):214-21. Epub 2005 Nov 17.
Title Quasispecies diversity determines pathogenesis through cooperative interactions in a viral population.
Authors Vignuzzi M, Stone JK, Arnold JJ, Cameron CE, Andino R.
Journal Nature. 2006 Jan 19;439(7074):344-8. Epub 2005 Dec 4.
Title Structural and biological identification of residues on the surface of NS3 helicase required for optimal replication of the hepatitis C virus.
Authors Mackintosh SG, Lu JZ, Jordan JB, Harrison MK, Sikora B, Sharma SD, Cameron CE, Raney KD, Sakon J.
Journal J Biol Chem. 2006 Feb 10;281(6):3528-35. Epub 2005 Nov 22.
Title Stimulation of poliovirus RNA synthesis and virus maturation in a HeLa cell-free in vitro translation-RNA replication system by viral protein 3CDpro.
Authors Franco D, Pathak HB, Cameron CE, Rombaut B, Wimmer E, Paul AV.
Journal Virol J. 2005 Nov 21;2:86.
Title Mechanisms of action of ribavirin against distinct viruses.
Authors Graci JD, Cameron CE.
Journal Rev Med Virol. 2006 Jan-Feb;16(1):37-48. Review.

2005
Title Hepatitis C virus nonstructural protein 5A (NS5A) is an RNA-binding protein.
Authors Huang L, Hwang J, Sharma SD, Hargittai MR, Chen Y, Arnold JJ, Raney KD, Cameron CE.
Journal J Biol Chem. 2005 Oct 28;280(43):36417-28. Epub 2005 Aug 25.
Title Remote site control of an active site fidelity checkpoint in a viral RNA-dependent RNA polymerase.
Authors Arnold JJ, Vignuzzi M, Stone JK, Andino R, Cameron CE.
Journal J Biol Chem. 2005 Jul 8;280(27):25706-16. Epub 2005 May 5.
Title Stimulation of poliovirus synthesis in a HeLa cell-free in vitro translation-RNA replication system by viral protein 3CDpro.
Authors Franco D, Pathak HB, Cameron CE, Rombaut B, Wimmer E, Paul AV.
Journal J Virol. 2005 May;79(10):6358-67.
Title Norovirus proteinase-polymerase and polymerase are both active forms of RNA-dependent RNA polymerase.
Authors Belliot G, Sosnovtsev SV, Chang KO, Babu V, Uche U, Arnold JJ, Cameron CE, Green KY.
Journal J Virol. 2005 Feb;79(4):2393-403.
Title Incorporation fidelity of the viral RNA-dependent RNA polymerase: a kinetic, thermodynamic and structural perspective.
Authors Castro C, Arnold JJ, Cameron CE.
Journal Virus Res. 2005 Feb;107(2):141-9. Review.
Title Multiple full-length NS3 molecules are required for optimal unwinding of oligonucleotide DNA in vitro.
Authors Tackett AJ, Chen Y, Cameron CE, Raney KD.
Journal J Biol Chem. 2005 Mar 18;280(11):10797-806. Epub 2005 Jan 4.

2004
Title Purification and characterization of hepatitis C virus non-structural protein 5A expressed in Escherichia coli.
Authors Huang L, Sineva EV, Hargittai MR, Sharma SD, Suthar M, Raney KD, Cameron CE.
Journal Protein Expr Purif. 2004 Sep;37(1):144-53.
Title Poliovirus RNA-dependent RNA polymerase (3Dpol): kinetic, thermodynamic, and structural analysis of ribonucleotide selection.
Authors Gohara DW, Arnold JJ, Cameron CE.
Journal Biochemistry. 2004 May 11;43(18):5149-58.
Title Poliovirus RNA-dependent RNA polymerase (3Dpol): pre-steady-state kinetic analysis of ribonucleotide incorporation in the presence of Mn2+.
Authors Arnold JJ, Gohara DW, Cameron CE.
Journal Biochemistry. 2004 May 11;43(18):5138-48.
Title Poliovirus RNA-dependent RNA polymerase (3Dpol): pre-steady-state kinetic analysis of ribonucleotide incorporation in the presence of Mg2+.
Authors Arnold JJ, Cameron CE.
Journal Biochemistry. 2004 May 11;43(18):5126-37.
Title Challenges for the development of ribonucleoside analogues as inducers of error catastrophe.
Authors Graci JD, Cameron CE.
Journal Antivir Chem Chemother. 2004 Jan;15(1):1-13. Review.
Title Lethal mutagens: broad-spectrum antivirals with limited potential for development of resistance?
Authors Freistadt MS, Meades GD, Cameron CE.
Journal Drug Resist Updat. 2004 Feb;7(1):19-24. Review.

2003
Title Manganese-dependent polioviruses caused by mutations within the viral polymerase.
Authors Crotty S, Gohara D, Gilligan DK, Karelsky S, Cameron CE, Andino R.
Journal J Virol. 2003 May;77(9):5378-88.

2002
Title Pleiotropic mechanisms of ribavirin antiviral activities.
Authors Hong Z, Cameron CE.
Journal Prog Drug Res. 2002;59:41-69. Review.
Title The palm subdomain-based active site is internally permuted in viral RNA-dependent RNA polymerases of an ancient lineage.
Authors Gorbalenya AE, Pringle FM, Zeddam JL, Luke BT, Cameron CE, Kalmakoff J, Hanzlik TN, Gordon KH, Ward VK.
Journal J Mol Biol. 2002 Nov 15;324(1):47-62.
Title Isolation of enzymatically active replication complexes from feline calicivirus-infected cells.
Authors Green KY, Mory A, Fogg MH, Weisberg A, Belliot G, Wagner M, Mitra T, Ehrenfeld E, Cameron CE, Sosnovtsev SV.
Journal J Virol. 2002 Sep;76(17):8582-95.
Title Quasispecies, error catastrophe, and the antiviral activity of ribavirin.
Authors Graci JD, Cameron CE.
Journal Virology. 2002 Jul 5;298(2):175-80. Review.
Title Synthesis and antiviral evaluation of a mutagenic and non-hydrogen bonding ribonucleoside analogue: 1-beta-D-Ribofuranosyl-3-nitropyrrole.
Authors Harki DA, Graci JD, Korneeva VS, Ghosh SK, Hong Z, Cameron CE, Peterson BR.
Journal Biochemistry. 2002 Jul 23;41(29):9026-33.
Title Structure-function relationships of the RNA-dependent RNA polymerase from poliovirus (3Dpol). A surface of the primary oligomerization domain functions in capsid precursor processing and VPg uridylylation.
Authors Pathak HB, Ghosh SK, Roberts AW, Sharma SD, Yoder JD, Arnold JJ, Gohara DW, Barton DJ, Paul AV, Cameron CE.
Journal J Biol Chem. 2002 Aug 30;277(35):31551-62. Epub 2002 Jun 19.
Title Hepatitis C virus NS3 and simian virus 40 T antigen helicases displace streptavidin from 5′-biotinylated oligonucleotides but not from 3′-biotinylated oligonucleotides: evidence for directional bias in translocation on single-stranded DNA.
Authors Morris PD, Byrd AK, Tackett AJ, Cameron CE, Tanega P, Ott R, Fanning E, Raney KD.
Journal Biochemistry. 2002 Feb 19;41(7):2372-8.