Recommended Reading

Featured Review:

aha logo       AHA Scientific Statement
Mitochondrial Function, Biology, and Role in Disease
A Scientific Statement From the American Heart Association

  1. Elizabeth Murphy, PhD, Chair*,
  2. Hossein Ardehali, MD, PhD,
  3. Robert S. Balaban, PhD*,
  4. Fabio DiLisa, MD,
  5. Gerald W. Dorn II, MD,
  6. Richard N. Kitsis, MD,
  7. Kinya Otsu, MD, PhD,
  8. Peipei Ping, PhD,
  9. Rosario Rizzuto, MD,
  10. Michael N. Sack, MD, PhD*,
  11. Douglas Wallace, PhD,
  12. Richard J. Youle, PhD

On behalf of the American Heart Association Council on Basic Cardiovascular Sciences, Council on Clinical Cardiology, and Council on Functional Genomics and Translational Biology

Click here for more information.

March 2017:

  1. Regulation of DENND3, the exchange factor for the small GTPase Rab12 through an intramolecular interaction
  2. Structure of human IFIT1 with capped RNA reveals adaptable mRNA binding and mechanisms for sensing N1 and N2 ribose 2′-O methylations
  3. A New General Method for Simultaneous Fitting of Temperature- and Concentration-Dependence of Reaction Rates Yields Kinetic and Thermodynamic Parameters for HIV Reverse Transcriptase Specificity
  4. Innate immunity to RNA virus is regulated by temporal and reversible sumoylation of RIG-I and MDA5
  5. The ER Stress Sensor PERK Coordinates ER-Plasma Membrane Contact Site Formation through Interaction with Filamin-A and F-Actin Remodeling
  6. Ultrastructural Characterization of Zika Virus Replication Factories
  7. Lipid Domain Co-localization Induced by Membrane Undulations
  8. Molecular Basis of Interactions Between SH3 Domain-Containing Proteins and the Proline-Rich Region of the Ubiquitin Ligase Itch
  9. A Cell-free Method for Expressing and Reconstituting Membrane Proteins Enables Functional Characterization of the Plant Receptor-like Protein Kinase FERONIA
  10. Mitochondrial dysfunction induces dendritic loss via eIF2α phosphorylation
  11. Non-Enzymatic Molecular Damage as a Prototypic Driver of Aging
  12. Deep-sea vent phage DNA polymerase specifically initiates DNA synthesis in the absence of primers
  13. G-quadruplex–forming promoter sequences enable transcriptional activation in response to oxidative stress
  14. Quantifying Intracellular Rates of Glycolytic and Oxidative ATP Production and Consumption Using Extracellular Flux Measurements
  15. mTOR Signaling in Growth, Metabolism, and Disease
  16. A Critical and Comparative Review of Fluorescent Tools for Live-Cell Imaging
  17. The RNA Epistructurome: Uncovering RNA Function by Studying Structure and Post-Transcriptional Modifications
  18. Mechanism of transcription initiation and promoter escape by E. coli RNA polymerase
  19. Phosphorylation-induced conformational dynamics in an intrinsically disordered protein and potential role in phenotypic heterogeneity
  20. Bacterial proteostasis balances energy and chaperone utilization efficiently

February 2017:

  1. Oxidative DNA damage is epigenetic by regulating gene transcription via base excision repair
  2. Investigating Viruses During the Transformation of Molecular Biology
  3. Dynamics of GreB-RNA polymerase interaction allow a proofreading accessory protein to patrol for transcription complexes needing rescue
  4. Enteroviruses infect human enteroids and induce antiviral signaling in a cell lineage-specific manner
  5. Single-Cell Multiomics: Multiple Measurements from Single Cells
  6. Mitochondrial protein interactome elucidated by chemical cross-linking mass spectrometry
  7. Genetics: Mitochondrial DNA in evolution and disease
  8. Mitochondrial and nuclear DNA matching shapes metabolism and healthy ageing
  9. Dynamic Lipid-dependent Modulation of Protein Topology by Post-translational Phosphorylation
  10. Synergistic Effects of the in cis T251I and P587L Mitochondrial DNA Polymerase γ Disease Mutations
  11. TRIM65-catalized ubiquitination is essential for MDA5-mediated antiviral innate immunity
  12. Proteomics Tracing the Footsteps of Infectious Disease
  13. Quantifying antiviral activity optimizes drug combinations against hepatitis C virus infection
  14. Profiling Subcellular Protein Phosphatase Responses to Coxsackievirus B3 Infection of Cardiomyocytes
  15. Mutation of a kinase allosteric node uncouples dynamics linked to phosphotransfer
  16. Kobuviral Non-structural 3A Proteins Act as Molecular Harnesses to Hijack the Host ACBD3 Protein
  17. A Structural Model for Vinculin Insertion into PIP2-Containing Membranes and the Effect of Insertion on Vinculin Activation and Localization
  18. Networks of Dynamic Allostery Regulate Enzyme Function
  19. Transcriptional Addiction in Cancer
  20. Labeling proteins inside living cells using external fluorophores for microscopy
  21. Nanometer resolution imaging and tracking of fluorescent molecules with minimal photon fluxes
  22. C. elegans neurons jettison protein aggregates and mitochondria under neurotoxic stress
  23. EPRS is a critical mTORC1–S6K1 effector that influences adiposity in mice
  24. Single-cell spatial reconstruction reveals global division of labour in the mammalian liver
  25. A-to-I RNA Editing Up-regulates Human Dihydrofolate Reductase in Breast Cancer
  26. Cytosolic DNA Promotes Signal Transducer and Activator of Transcription 3 (STAT3) Phosphorylation by TANK-binding kinase 1 (TBK1) to Restrain STAT3 Activity
  27. Reviews: Viral Polymerases
  28. Rules of RNA specificity of hnRNP A1 revealed by global and quantitative analysis of its affinity distribution
  29. Inactivation of Interferon Receptor Promotes the Establishment of Immune Privileged Tumor Microenvironment

January 2017:

  1. Noncanonical Antiviral Mechanisms of ISGs: Dispensability of Inducible Interferons
  2. Innate Antiviral Defenses Independent of Inducible IFNα/β Production
  3. Post-translational Control of Intracellular Pathogen Sensing Pathways
  4. Sequence-Specific Sensing of Nucleic Acids
  5. MicroRNA Regulation of RNA Virus Replication and Pathogenesis
  6. Human Mitochondrial Transcription Factor B2 is Required for Promoter Melting During Initiation of Transcription
  7. Probing conformational dynamics of an enzymatic active site by an in situ single fluorogenic probe under piconewton force manipulation
  8. Mimicking transient activation of protein kinases in living cells
  9. Two distinct membrane potential–dependent steps drive mitochondrial matrix protein translocation
  10. An RNA-Based Fluorescent Biosensor for High-Throughput Analysis of the cGAS-cGAMP-STING Pathway
  11. Structural Basis for the Interaction between Golgi Reassembly-Stacking Protein GRASP55 and Golgin45
  12. Genetic stability of genome-scale deoptimized RNA virus vaccine candidates under selective pressure
  13. Cellular encoding of Cy dyes for single-molecule imaging
  14. Harbouring public good mutants within a pathogen population can increase both fitness and virulence
  15. The brain parenchyma has a type I interferon response that can limit virus spread
  16. Potent NLRP3 inflammasome activation by the HIV reverse-transcriptase inhibitor abacavir
  17. Interrogating cellular perception and decision making with optogenetic tools
  18. Why proteomics is not the new genomics and the future of mass spectrometry in cell biology
  19. Organoids: A historical perspective of thinking in three dimensions
  20. Potent NLRP3 inflammasome activation by the HIV reverse-transcriptase inhibitor abacavir
  21. Residues in the RecQ C-terminal Domain of the Human Werner Syndrome Helicase are Involved in Unwinding G-quadruplex DNA
  22. Kinetic Modeling and Analysis of the Akt/Mechanistic Target of Rapamycin Complex 1 (mTORC1) Signaling Axis Reveals Cooperative, Feedforward Regulation
  23. Shuttling along DNA and directed processing of D-loops by RecQ helicase support quality control of homologous recombination
  24. Protein interactions during the flavivirus and hepacivirus life cycle
  25. Imaging proteins at the single-molecule level
  26. Core Concept: How nonequilibrium thermodynamics speaks to the mystery of life
  27. CRISPR-Based Technologies for the Manipulation of Eukaryotic Genomes
  28. Triphosphate Re-orientation of the Incoming Nucleotide as a Fidelity Checkpoint in Viral RNA-dependent RNA polymerases
  29. Mitochondrial O-GlcNAc transferase (mOGT) regulates mitochondrial structure, function and survival in HeLa cells
  30. Sterol-binding by the tombusviral replication proteins is essential for replication in yeast and plants
  31. Rhinovirus C, Asthma, and Cell Surface Expression of Virus Receptor, CDHR3
  32. Virology: Ins and outs of picornaviruses
  33. Reversible methylation of m6Am in the 5′ cap controls mRNA stability
  34. The role of interfacial lipids in stabilizing membrane protein oligomers
  35. The Many Faces of the Flavivirus NS5 Protein in Antagonism of Type Interferon Signaling
  36. Enzymes at work are enzymes in motion
  37. The role of dimer asymmetry and protomer dynamics in enzyme catalysis
  38. Human tissues in a dish: The research and ethical implications of organoid technology
  39. Evolutionary drivers of thermoadaptation in enzyme catalysis
  40. Dynamic interactions between a membrane binding protein and lipids induce fluctuating diffusivity
  41. Comparative characterization of phosphatidic acid sensors and their localization during frustrated phagocytosis
  42. Three-Phase Coexistence in Lipid Membranes
  43. Molecular-Scale Biophysical Modulation of an Endothelial Membrane by Oxidized Phospholipids
  44. Mitochondrial respiratory gene expression is suppressed in many cancers
  45. DNA structure directs positioning of the mitochondrial genome packaging protein Abf2p
  46. Attacked from All Sides: RNA Decay in Antiviral Defense
  47. Virus Escape and Manipulation of Cellular Nonsense-Mediated mRNA Decay
  48. Lipids and flaviviruses, present and future perspectives for the control of dengue, Zika, and West Nile viruses.
  49. Lipid flippases promote antiviral silencing and the biogenesis of viral and host siRNAs in Arabidopsis
  50. Comparative analysis of mitochondrial N-termini from mouse, human, and  yeast
  51. Zika Virus Causes Testis Damage and Leads to Male Infertility in Mice
  52. Single-Cell Genomics: Approaches and Utility in Immunology

December 2016:

  1. Diverse activities of viral cis-acting RNA regulatory elements revealed using multi-color, long-term, single cell imaging
  2. Navigating challenges in the application of superresolution microscopy
  3. Dynamic lipid-dependent modulation of protein topology by post-translational phosphorylation
  4. Coordinated Activities of Multiple Myc-dependent and Myc-independent Biosynthetic Pathways in Hepatoblastoma
  5. Rate-limiting Pyrophosphate Release by HIV Reverse Transcriptase Improves Fidelity
  6. HIV-1 Reverse Transcriptase Polymerase and RNase H (Ribonuclease H) Active Sites Work Simultaneously and Independently
  7. Labeling proteins inside living cells using external fluorophores for microscopy
  8. The significance of the Location of Mutations for the Native-State Dynamics of Human Lysozyme
  9. PtdInsP2 and PtdSer cooperate to trap synaptotagmin-1 to the plasma membrane in the presence of calcium
  10. Viruses are a dominant driver of protein adaptation in mammals
  11. Molecular Evolution of Human Coronavirus Genomes
  12. Emerging Mechanisms in Initiating and Terminating Autophagy
  13. Watching cellular machinery in action, one molecule at a time
  14. Structural identifiability of equilibrium ligand-binding parameters
  15. The structure of binding curves and practical identifiability of equilibrium ligand-binding parameters
  16. The Molecular Basis of Aichi Virus 3A Protein Activation of Phosphatidylinositol 4 Kinase IIIβ, PI4KB, through ACBD3
  17. Heat Shock Protein 90 Modulates Lipid Homeostasis by Regulating the Stability and Function of Sterol Regulatory Element-Binding Protein (SREBP) and SREBP Cleavage-Activating Protein
  18. A Mouse Model of Zika Virus Sexual Transmission and Vaginal Viral Replication
  19. Shape Transformations of Lipid Bilayers Following Rapid Cholesterol Uptake
  20. Antiviral Innate Immune Response Interferes with the Formation of Replication-Associated Membrane Structures Induced by a Positive-Strand RNA Virus
  21. Rigorous Science: a How-To Guide

November 2016:

  1. Enrichment of Phosphatidylethanolamine in Viral Replication Compartments via Co-opting the Endosomal Rab5 Small GTPase by a Positive-Strand RNA Virus.
  2. O-GlcNAcylation of Ogg1 Impairs Oxidative Mitochondrial DNA Lesion Repair in Diabetic Hearts
  3. Zika Virus Genomic RNA Possesses Conserved G-Quadruplexes Characteristic of the Flaviviridae Family

October 2016:

  1. Human mitochondrial ribosomes can switch their structural RNA composition 
  2. Mitochondrial DNA exhibits resistance to induced point and deletion mutations
  3. RNA damage in biological conflicts and the diversity of responding RNA repair systems
  4. The role of sequence context, nucleotide pool balance and stress in 2′-deoxynucleotide misincorporation in viral, bacterial and mammalian RNA
  5. Absolute quantitative measurement of transcriptional kinetic parameters in vivo
  6. Targeting a novel RNA-protein interaction for therapeutic intervention of Hantavirus disease
  7. Oxidized Guanine Base Lesions Function in 8-Oxoguanine DNA Glycosylase1-Mediated Epigenetic Regulation of Nuclear Factor kappaB-Driven Gene Expression
  8. Coordinated Activities of Multiple Myc-dependent and Myc-independent Biosynthetic Pathways in Hepatoblastoma
  9. Rate-limiting Pyrophosphate Release by HIV Reverse Transcriptase Improves Fidelity
  10. HIV-1 Reverse Transcriptase Polymerase and RNase H Active Sites Work Simultaneously and Independently
  11. Biochemical Characterization of Middle East Respiratory Syndrome Coronavirus Helicase
  12. Rescue of the 1947 Zika Virus Prototype Strain with a Cytomegalovirus Promoter-Driven cDNA Clone
  13. Norovirus Polymerase Fidelity Contributes to Viral Transmission In Vivo

September 2016:

  1. In B cells, phosphatidylinositol 5-phosphate 4-kinase–α synthesizes PI(4,5)P2 to impact mTORC2 and Akt signaling
  2. Emergent rules for codon choice elucidated by editing rare arginine codons in Escherichia coli
  3. eIF4B stimulates translation of long mRNAs with structured 5′ UTRs and low closed-loop potential but weak dependence on eIF4G
  4. LSD1—a pivotal epigenetic regulator of brown and beige fat differentiation and homeostasis
  5. What have single-molecule studies taught us about gene expression?
  6. Lysine-specific demethylase 1 promotes brown adipose tissue thermogenesis via repressing glucocorticoid activation
  7. Visualization of single endogenous polysomes reveals the dynamics of translation in live human cells
  8. Genome-wide analysis of single non-templated nucleotides in plant endogenous siRNAs and miRNAs
  9. Systematic analysis of plant mitochondrial and chloroplast small RNAs suggests organelle-specific mRNA stabilization mechanisms
  10. The RNA-binding protein TTP is a global post-transcriptional regulator of feedback control in inflammation
  11. Phosphatidylcholine Affects Inner Membrane Protein Translocases of Mitochondria
  12. Hepatitis B Virus Polymerase Localizes to the Mitochondria, and Its Terminal Protein Domain Contains the Mitochondrial Targeting Signal
  13. The PB2 Subunit of the Influenza A Virus RNA Polymerase Is Imported into the Mitochondrial Matrix
  14. Poliovirus Polymerase Leu420 Facilitates RNA Recombination and Ribavirin Resistance
  15. PtdIns(4,5)P2 signaling regulates ATG14 and autophagy
  16. High-throughput single-cell gene-expression profiling with multiplexed error-robust fluorescence in situ hybridization
  17. mRNA capping: biological functions and applications
  18. Why Calcium? How Calcium Became the Best Communicator
  19. Iron Deprivation Induces Transcriptional Regulation of Mitochondrial Biogenesis

August 2016:

  1. Syntaxin-17 delivers PINK1/parkin-dependent mitochondrial vesicles to the endolysosomal system
  2. mito-QC illuminates mitophagy and mitochondrial architecture in vivo
  3. Structural basis of HIV inhibition by translocation-defective RT inhibitor 4′-ethynyl-2-fluoro-2′-deoxyadenosine (EFdA)
  4. Structure of an Intrinsically Disordered Stress Protein Alone and Bound to a Membrane Surface
  5. A disulfide bond in the TIM23 complex is crucial for voltage gating and mitochondrial protein import
  6. Link of a ubiquitous human coronavirus to dromedary camels
  7. The use of an artificial nucleotide for polymerase-based recognition of carcinogenic O^6-alkylguanine DNA adducts
  8. Single base resolution analysis of 5-hydroxymethylcytosine in 188 human genes: implications for hepatic gene expression
  9. SLIRP stabilizes LRPPRC via an RRM PPR protein interface
  10. Hepatitis C Virus Nonstructural 5A Protein Interacts with Abelson Interactor 1 and Modulates Epidermal Growth Factor-Mediated MEK/ERK Signaling Pathway
  11. Irregular G-quadruplexes found in the untranslated regions of human mRNAs influence translation
  12. Illuminating the Sites of Enterovirus Replication in Living Cells by Using a Split-GFP-Tagged Viral Protein

July 2016:

  1. The Central Polybasic Region of the Soluble SNARE Vam7 Affects Binding to Phosphatidylinositol 3-phosphate by the PX domain
  2. Evidence that G-quadruplex DNA Accumulates in the Cytoplasm and Participates in Stress Granule Assembly in Response to Oxidative Stress
  3. Mitochondrial Dynamics Controls T Cell Fate through Metabolic Programming
  4. The role of sequence context, nucleotide pool balance and stress in 2′-deoxynucleotide misincorporation in viral, bacterial and mammalian RNA.
  5. Cytosine deamination and the precipitous decline of spontaneous mutation during Earth’s history
  6. Dengue Virus Genome Uncoating Requires Ubiquitination
  7. Highly Efficient Mouse Genome Editing by CRISPR Ribonucleoprotein Electroporation of Zygotes
  8. Interferon-Induced Spermidine-Spermine Acetyltransferase and Polyamine Depletion Restrict Zika and Chikungunya Viruses
  9. Functions of Polyamines in Mammals
  10. Mechanism of substrate specificity of phosphatidylinositol phosphate kinases
  11. 5′ to 3′ unfolding directionality of DNA secondary structures by replication protein A: G-quadruplexes and duplexes
  12. Structural and Functional Characterization of Programmed Ribosomal Frameshift Signals in West Nile Virus Strains Reveals High Structural Plasticity Among cis-Acting RNA Elements
  13. Molecular Mechanisms of Enzyme Activation by Monovalent Cations
  14. Interaction between Nonstructural Proteins NS4B and NS5A Is Essential for Proper NS5A Localization and Hepatitis C Virus RNA Replication
  15. Mutagenesis of S-Adenosyl-l-Methionine-Binding Residues in Coronavirus nsp14 N7-Methyltransferase Demonstrates Differing Requirements for Genome Translation and Resistance to Innate Immunity
  16. Homology-Based Identification of a Mutation in the Coronavirus RNA-Dependent RNA Polymerase That Confers Resistance to Multiple Mutagens Nicole R. Sexton, Everett Clinton Smith, Herv  Blanc, Marco Vignuzzi, Olve B. Peersen, and Mark R. Denison
  17. Structural Basis of the High Affinity Interaction between the Alphavirus Nonstructural Protein-3 (nsP3) and the SH3 Domain of Amphiphysin-2

June 2016:

  1. PrimPol prevents APOBEC/AID family mediated DNA mutagenesis
  2. Novel modes of RNA editing in mitochondria
  3. Functional Implications of O-GlcNAcylation-dependent Phosphorylation at a Proximal Site on Keratin 18
  4. O-GlcNAcylation Antagonizes Phosphorylation of CDH1 (CDC20 Homologue 1)
  5. Propionate Increases Hepatic Pyruvate Cycling and Anaplerosis and Alters Mitochondrial Metabolism
  6. The HIV-1 Tat protein is monomethylated at lysine-71 by the lysine methyltransferase KMT7
  7. Staufen1 promotes HCV replication by inhibiting protein kinase R and transporting viral RNA to the site of translation and replication in the cells
  8. Cre-dependent DNA recombination activates a STING-dependent innate immune response
  9. Super resolution microscopy reveals compartmentalization of peroxisomal membrane proteins
  10. The yeast mitochondrial RNA polymerase and transcription factor complex catalyzes efficient priming of DNA synthesis on single-stranded DNA
  11. Chemical properties of lipids strongly affect the kinetics of the membrane-induced aggregation of α-synuclein
  12. Ancient mtDNA sequences from the First Australians revisited
  13. Identification of A Conserved RdRp-RNA Interface Required for Flaviviral Replication
  14. Structural basis of viral RNA-dependent RNA polymerase catalysis and translocation
  15. Conformational dynamics of a G-protein α subunit is tightly regulated by nucleotide binding

May 2016:

  1. Elongation Factor Spt4/5 Interacts with DNA to Prevent RNA Polymerase II from Stalling during Transcription♦Biochemical Analysis of Yeast Suppressor of Ty 4/5 (Spt4/5) Reveals the Importance of Nucleic Acid Interactions in the Prevention of RNA Polymerase II Arrest
  2. Loss of Mitochondrial Function Impairs Lysosomes
  3. Mechanism of Concerted RNA-DNA Primer Synthesis by the Human Primosome
  4. A Proline-Rich N-Terminal Region of the Dengue Virus NS3 Is Crucial for Infectious Particle Production
  5. Biochemical Characterization of the Human Mitochondrial Replicative Twinkle Helicase: Substrate Specificity, DNA Branch-Migration, and Ability to Overcome Blockades to DNA Unwinding
  6. Human DDX3 protein is a valuable target to develop broad spectrum antiviral agents
  7. Primer release is the rate-limiting event in lagging-strand synthesis mediated by the T7 replisome
  8. Interactions between RNA polymerase and the core recognition element are a determinant of transcription start site selection
  9. Nucleoside Triphosphate Phosphohydrolase I (NPH I) Functions as a 5′ to 3′ Translocase in Transcription Termination of Vaccinia Early Genes.
  10. The N-terminus of the Vaccinia Virus protein F1L is an Intrinsically Unstructured Region that is not involved in Apoptosis Regulation
  11. Design of a Genetically Stable High-Fidelity Coxsackievirus B3 Polymerase That Attenuates Virus Growth in vivo
  12. Mechanisms of small molecule–DNA interactions probed by single-molecule force spectroscopy
  13. G-quadruplexes as novel cis-elements controlling transcription during embryonic development
  14. Homologous DNA strand exchange activity of the human mitochondrial DNA helicase TWINKLE
  15. Pif1 is a force-regulated helicase
  16. An RNA trapping mechanism in Alphavirus mRNA promotes ribosome stalling and translation initiation
  17. Insertion of oxidized nucleotide triggers rapid DNA polymerase opening
  18. IFN-β Production During the dsRNA Response in Hepatocytes Involves Coordinated and Feed Forward Signaling Through TLR3, PKR, iNOS and Src
  19. Structural and Functional Characterization of Programmed Ribosomal Frameshift Signals in West Nile Virus Strains Reveals High Structural Plasticity Among cis-Acting RNA Elements
  20. Interactions between RNA polymerase and the core recognition element are a determinant of transcription start site selection
  21. Primer release is the rate-limiting event in lagging-strand synthesis mediated by the T7 replisome
  22. DNA Sequence Alignment during Homologous Recombination
  23. Human Cells Require Non-stop Ribosome Rescue Activity in Mitochondria

April 2016:

  1. Cleavage and polyadenylation specificity factor 30: An RNA-binding zinc-finger protein with an unexpected 2Fe–2S cluster
  2. Dynamical network of residue–residue contacts reveals coupled allosteric effects in recognition, catalysis, and mutation
  3. Zika Virus Focuses the Gain-of-Function Debate
  4. Investigating the Influence of Ribavirin on Human Respiratory Syncytial Virus RNA Synthesis by Using a High-Resolution Transcriptome Sequencing Approach

March 2016:

  1. Conformations of a Metastable SH3 Domain Characterized by smFRET and an Excluded-Volume Polymer Model
  2. DNA Instability Maintains the Repeat Length of the Yeast RNA Polymerase II C-terminal Domain
  3. Structural characterization of a dimer of RNA duplexes composed of 8-bromoguanosine modified CGG trinucleotide repeats: a novel architecture of RNA quadruplexes
  4. G-quadruplexes and helicases
  5. Introduction to the Thematic Minireview Series on Intrinsically Disordered Proteins
  6. Dancing Protein Clouds: The Strange Biology and Chaotic Physics of Intrinsically Disordered Proteins
  7. Insights into Coupled Folding and Binding Mechanisms from Kinetic Studies
  8. Modulation of Intrinsically Disordered Protein Function by Post-translational Modifications
  9. Expanding the Range of Protein Function at the Far End of the Order-Structure Continuum
  10. Role of Intrinsic Protein Disorder in the Function and Interactions of the Transcriptional Coactivators CREB-binding Protein (CBP) and p300
  11. Design Principles Involving Protein Disorder Facilitate Specific Substrate Selection and Degradation by the Ubiquitin-Proteasome System

Feburary 2016:

  1. Nonstructural 5A Protein of Hepatitis C Virus Regulates Soluble Resistance-Related Calcium-Binding Protein Activity for Viral Propagation
  2. Polyprotein-Driven Formation of Two Interdependent Sets of Complexes Supporting Hepatitis C Virus Genome Replication
  3. An intrinsically disordered motif mediates diverse actions of monomeric C-reactive protein
  4. Functional Evolution in Orthologous Cell-encoded RNA-dependent RNA Polymerases
  5. Intracellular pH modulates autophagy and mitophagy
  6. The binding of syndapin SH3 domain to dynamin proline-rich domain involves short and long distance elements
  7. Circadian control of oscillations in mitochondrial rate-limiting enzymes and nutrient utilization by PERIOD proteins
  8. Role of Intrinsic Protein Disorder in the Function and Interactions of the Transcriptional Coactivators CREB-Binding Protein (CBP) and p300
  9. Dancing Protein Clouds: The Strange Biology and Chaotic Physics of Intrinsically Disordered Proteins
  10. Modulation of Intrinsically Disordered Protein Function by Post-Translational Modifications
  11. Thumb Site 2 Inhibitors of Hepatitis C Viral RNA-Dependent RNA Polymerase Allosterically Block the Transition from Initiation to Elongation
  12. DNA Shape versus Sequence Variations in the Protein Binding Process

January 2016:

  1. Editing of cellular self RNAs by adenosine deaminase ADAR1 suppresses innate immune stress responses
  2. Mitochondria, complexity, and evolutionary deficit spending
  3. Reply to Lane and Martin: Mitochondria do not boost the bioenergetic capacity of eukaryotic cells
  4. Modulation of DNA Polymerase Noncovalent Kinetic Transitions by Divalent Cations
  5. Diminished viral replication and compartmentalization of hepatitis C virus in hepatocellular carcinoma tissue
  6. Enterovirus D68 receptor requirements unveiled by haploid genetics
  7. Phosphorylation Increases Persistence Length and End-to-End Distance of a Segment of Tau Protein
  8. Host Sphingomyelin Increases West Nile Virus Infection in vivo
  9. Mechanism of Ribonucleotide Incorporation by Human DNA Polymerase η
  10. NusG is a Sequence-specific RNA Polymerase Pause Factor that Binds to the Non-template DNA Within the Paused Transcription Bubble
  11. Guanine quadruplex structures localize to heterochromatin
  12. Structural basis for m7G recognition and 2′-O-methyl discrimination in capped RNAs by the innate immune receptor RIG-I
  13. Yeast Helicase Pif1 Unwinds RNA:DNA Hybrids with Higher Processivity than DNA:DNA Duplexes
  14. Hepatitis C virus utilizes VLDLR as a novel entry pathway
  15. Mechanisms and Functions of Vinculin Interactions with Phospholipids at Cell Adhesion Sites
  16. One-pot system for synthesis, assembly, and display of functional single-span membrane proteins on oil–water interfaces
  17. Scientists: Engage the Public!